Experimental pain killer drug made from snail venom 100 times more potent than morphine
An experimental drug made from snail venom has shown early signs of promise in numbing pain, raising hopes in the hunt for new, nonaddictive medications, researchers said Sunday. The drug, which has not been tested yet on humans, was judged to be about 100 times more potent than morphine or gabapentin, which are currently considered the gold standard for chronic nerve pain. The active ingredient, conotoxin, comes from carnivorous cone snails, which are common in the western Pacific and Indian Ocean. The marine animals can reach out and stab prey, injecting a venom that paralyses fish.
Long enough for the snail to eat it up. A tiny protein derived from the snail's venom has formed the basis of five new experimental compounds, said lead researcher David Craik of the University of Queensland in Australia. A preliminary study using one of these new compounds on lab rats appeared to significantly reduce pain, said a press statement released ahead of Craik's presentation at an American Chemical Society meeting in Dallas, Texas. This is an important incremental step that could serve as the blueprint for the development of a whole new class of drugs capable of relieving one of the most severe forms of chronic pain.
That is currently very difficult to treat, said Craik. Animal venoms are poisons that can block certain channels in the nervous system, and act differently than opioid painkillers such as morphine and hydrocodone, which carry the risk of addiction and death from overdose. Pharmaceutical companies have begun investigating venoms in recent years as potential sources of new drugs for managing neuropathic pain, which affects 15 per cent of the US population and can arise from cancer, AIDS, diabetes, and other debilitating diseases. One conotoxinderived drug, ziconotide, has already been approved for human use. However, it is not available.
Laser Treatment for Neuropathy Pain Patient Testimonial
I'm Gary from Ranch Mirage. I've had neuropathy in my feet for approximately 10 years. We treated it with various forms of medication. I've been on those medications for almost that length of time, including a few epidurals to try to take care of the neuropathy. I've been coming to Dr. Danciger for the last couple of weeks for laser treatments, which have been remarkably successful. I've gone for longer periods of time without pain or pain medication, and I look forward to even better results as it takes its time to.
How Benfotiamine Helps Treat Neuropathy
Hi, this is Dr. Silvester and I'm going to talk to you today about one of the supplements that we use for our patients that have neuropathy. Neuropathy can be caused by a lot of different things. The most common, in our office, is diabetes, but there are other things that can cause neuropathy like thyroid dysfunction, cancer treatments, chemotherapy can cause neuropathy. Then there's a large group of patients that have no discernible cause of neuropathy. There's probably a hundred different things that can cause neuropathy. Basically, supplementation can be helpful in those things.
There are a lot of prescription drugs for neuropathy, and we use them quite frequently, but they're only good for pain relief. The really don't seem to have any effect on helping the nerve get better. The more frequent theory, or current theory, of why nerves suffer is because of a thing called mitochondria dropout. That's a little scientific, but mitochondria are little energy packs inside of the cell, and they make the energy that the cell uses to heal itself and to maintain an electronic gradient, which a nerve has.
To do in order to conduct impulses. When you get these little mitochondria that live inside your cell, when they start to die because of oxidated stress or damage to them, then the nerve starts to suffer. The first one I'm going to talk about is called Benfotiamine. Benfotiamine is a derivative or form of vitamin B1, but it's much more bioavailable and more effective. Benfotiamine can be used as a supplement, and in most studies that have been done, about 70 of patients, when they start taking Benfotiamine, they have significant improvement in their symptoms.
We use Benfotiamine almost routinely on our patients whey they come in with neuropathy. We suggest they start taking that supplement. There's different places you can get that. We sell it here at our office, we also tell our patients places on the Internet where they can get it. Studies have been done using a dosage of anywhere up to 600 mg. We start out at about 320 mg per day and we've noticed that's usually enough. That usually does pretty well for helping our patients get rid of a lot of their symptoms. How it works it.
How Acetyl L Carnitine Helps Treat Neuropathy
Hi this is Dr. Silvester and I'm going to talk to you a little bit today about one of the supplements we use for our patients with diabetic neuropathy that seems to have a big effect in helping them and their nerves get better. There was actually a study done with this supplement where they took 1,275 patients who took this supplement, and they actually showed an increase in nerve fiber density, after taking this supplement for 52 weeks. They also showed that they had significant decrease in their pain, and they had significantly.
Improved quality of life after taking this supplement. It's acetyl l carnitine. Acetyl l carnitine works in the same way as many other antioxidants and many other nerve healing supplements. They help the nerve make more energy so it can heal itself and regrow. If you want to start your nerves on the path of healing, not just treating them with prescription medication, which really all they do is help the nerve feel better while it's dying, you can actually heal them with acetyl l carnitine and good studies have backed that up. With.
When you hear someone say they get migraines, you probably think of headaches, really BAD headaches. But in fact, the symptoms associated with migraine neuropathy are widely varied. What can some of those symptoms feel like It felt like my skull couldn't accommodate the balloon that someone was blowing up inside of my head. Instead of just the sensitivity to light, I was now getting sensitivity to sound and to feeling. What it feels like in my ears is pain and pressure that radiates to my eye and down to the joint below my ear and into my jaw.
I had problems driving on the highway where I felt like I couldn't keep track of the road, like it seemed like the road was kind of going away from me. There is a family history with migraines in the family, mainly the women. And the one time that I had a migraine so severely they did not know if it was a migraine or a stroke. Very scary situation.. The spinning sensation occurred whenever I moved my head. Even slight movement like this or like this. There's a squishiness in my ear that never leaves, and I also noticed that I smell things.
That other people don't smell and I taste things that are have a odd taste to them, that are not recognized by others. I would pull into my driveway, get out of the car, and I would even have a feeling that I was still moving or I would look at the car and think maybe my car was still rolling. I did recently find out that aphasia could be an aspect of this atypical migraine symptom, and my husband and I almost have a joke about it. I'll be speaking, and I'll just raise.
My eyebrows and point to him, and he'll say the word I can't find. Almost every time I went to the doctor's, I was given an antibiotic and I was also given a slip to have a CAT scan. I am still left with the same problems, the same ear pain, the same pressure, the same vestibular disturbance. The antibiotics did nothing. I believe I've seen three or four different Ear, Nose, and Throat Doctors who have sent me for Xrays, MRIs, CAT scans I'm not sure what all tests, but they've all come back negative.
By chance he said, Have you tried magnesium First I was so surprised that he was taking me seriously, that I just started to laugh. I've been on the Topamax now for 6 months and I've had no sinus symptoms whatsoever. And I can't tell you how much that has changed my life. So it got to the point where I can wear socks, I don't have to think twice of which is the worst bra, which is the best bra. I can actually get dressed, um, the sensitivity is I would say 95 gone.
New Effective Treatment for Tarsal Tunnel Syndrome
Are you suffering from burning tingling and numbing in the bottom of your foot For years the practice of performing the old procedure for tarsal tunnel produced a 40 to 60 failure rate because only this tunnel at the laciniate ligament in the ankle was released. Our new approach is designed to relieve pressures on the nerves in not only the tarsal tunnel which is similar to releasing the carpal tunnel in the hand, but now we know at least three more tunnels in the foot that must be addressed. This allows for normal function to return.
To the nerves. This is done for relieving burning, tingling and numbness and this is critical. This has increased our success rate to 85 to 90 success rate from the old failure rate of 40 to 60. Now we know to release the superior calcaneal chamber containing the medial plantar nerve supplying the bottom inside of your foot and toes. The inferior calcaneal chamber containing the lateral plantar nerve supplying the bottom outside of your foot and toes. And the smaller medial calcaneal nerve tunnels which may be 1 or more branches supplying.
The inside and bottom of the your heel. These ligaments or fibroustunnels are carefully released to create more space which relieves the pressures at each of these nerve tunnels or chokepoints allowing for the return of normal nerve function. Post operatively we incorporate Physical rehabilitation such as neural gliding, and aqua therapy, to encourage restoration of motor and sensory nerve function. Therapeutic lasers to enhance your healing process through photobiomodulation and Nutraceuticals to provide fuel for your nerves to heal. Remember the longer yours nerves are compressed, the more damage occurs to the axon or core.
Reducing Neuropathy Discomfort with Alpha Lipoic Acid
Hi, this is Dr. Silvester and I'm going to talk to you about another one of the supplements that we use in our patients who have diabetic neuropathy and that's called alpha lipoic acid. Alpha lipoic acid has been used for 20 years, treating a lot of different conditions HIV, sciatica, cancer, liver problems, hepatitis, strokes, vascular disease, diabetes, cataracts, glaucoma, and multiple sclerosis. Also, it's been used in patients who have Alzheimer's, to try to help them somewhat. It's not completely effective in any of those things it's a supplement and used as an adjunctive treatment for all of those things. It also plays an.
Important role in nerve metabolism, because what alpha lipoic acid does, is it works in a thing called the Krebs Cycle in your cell. What the Krebs Cycle is is it's the cycle that generates most of the energy that a cell needs. If you think of it like a gas tank in a car, alpha lipoid acid supports putting fuel in that gas tank. The energy requirements in cells varies a lot on the type of the cell. Your skin cells don't require very much energy, muscle cells require some, tendons.
Require very little because they just sit there, but nerve cells are always using energy. They're the most nerve sensitive cell in your body. By taking alpha lipoid acid and supporting that fuel tank, you can actually increase your nerve's ability to function normally and to heal. The other thing that alpha lipoid acid does is after you take enough that your Krebs Cycle is full, it then becomes an antioxidant. If you do some research on oxidative stress, we think that plays a significant role in a lot of different disease processes.
Including neuropathy. Alpha lipoic acid is a supplement that we use quite frequently in our patients with diabetic neuropathy, and what we tell them is that they've got to be a little bit careful, because alpha lipoic acid can lower your blood sugar. It's a benefit if you have a little trouble with your blood sugar, it's probably not a benefit if you're under good control. Also, it can cause a little problem with your thyroid. Levothyroxine can go down and also you probably shouldn't take it if you're having chemotherapy.
Chronic Coughing Possible causes and treatment
Chronic coughing is defined as coughing on a daily basis for three weeks or longer. And in smokers, they cough every day and that's a pretty common complaint. But if it's a nonsmoker, coughing that lasts longer than three weeks in duration is probably asthma, heartburn or postnasal drip. And it's interesting because if someone does not smoke cigarettes and they have a normal chest xray, there are really only three possible causes of this chronic coughing. About 50 percent of the time it's asthma that hasn't been diagnosed yet. So.
If you're just flipping a coin, 50 percent of the time, you'll be right in treating it for asthma. But the other 50 percent are made up of postnasal drip, which is particularly common in older folks above the age of 60, and then the real booger in all this is the, the reflux or heartburn can cause coughing. It's frustrating because the heartburn can be totally asymptomatic and yet the person can be coughing because of reflux. To get the symptom we all know and love as reflux or heartburn you need a whole cup of acid in your esophagus or swallowing.
Tube to cough you only need a teaspoon full. So, but cough chronic coughing with a normal xray in a nonsmoker is never an infection. So antibiotics are usually fairly useless. When we evaluate someone for chronic cough, the first question I give them is make sure their xrays are normal but the first question is, are there any history of childhood asthma or allergies Because it is so common. If there is and sometimes even if there isn't, I will initiate asthma therapy because that will almost immediately take the coughing.
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