Blood turned into nerve cells by Canadian researchers.
Canadian scientists have discovered a way to turn a simple blood sample from a man or woman into a variety of nerve cells, including those that are responsible for pain, numbness and other sensations. This technology will allow researchers to test potential drugs for treating pain using the nerve cells in a lab, all based on an individual patient's own genetic signature, says Mick Bhatia, who led the team of researchers at McMaster University in Hamilton. Now we can take easy to obtain blood samples and make the main cell types of neurological.
Systems the central nervous system and the peripheral nervous system in a dish that is specialized for each patient. According to Mick Bhatia, Nobody has ever done this with adult blood, ever Up until now, there has been no good way to get access to human neural cells to test or study. While researchers can buy certain kinds of rat neural cell lines, they don't consistently respond the way human neural cells do. The new technique involves extracting stem cells from blood ones that normally have the potential to become red blood cells or various kinds.
Of white blood cells involved in fighting off pathogens. The blood stem cells are converted over about a month into neural stem cells using a patented technique. Those cells can survive for several months in a petri dish. These neural stem cells are then manipulated in the lab to give rise to several types of nerve cells, including those that make up the peripheral nervous system throughout the arms, legs and the rest of the body. We can actually take a patient's blood sample, as routinely performed in a doctor's office,.
And with it we can produce one million sensory neurons. We can also make central nervous system cells. The researchers hope to discover new pain drugs that take aim only at the peripheral nerve system, while not affecting the brain and the rest of the central nervous system. You don't want to feel sleepy or unaware, you just want your pain to go away, says Bhatia. His lab hopes to further develop the bloodgenerated neural stem cells into motor and other kinds of neurons that could conceivably one day be transplanted into patients to restore healthy.
Peripheral Nervous System Disorders Diagnosis and Treatment
The peripheral nervous system is the part of the nervous system that excludes or is outside of the brain and the spinal cord. We take care of patients that have disorders that affect the motor neurons, which live in the spinal cord the peripheral nerves that extend out into the arms and legs as well as the muscles and the connection between the nerves and the muscles. Some of the disorders that a nerve and muscle a disease specialist will evaluate and develop care plans for include muscle disorders such as muscular dystrophy,.
Polymyositis, dermatomyositis, peripheral neuropathies such as Charcot Marie Tooth disease or hereditary neuropathy and as well as the neuromuscular junction disorders such as myasthenia gravis. Some symptoms that can be associated with the peripheral nervous system include generalized weakness, fatigue, numbness, tingling, sometimes pain can be caused by disorders of the peripheral nerve. The evaluation of a patient with a possible peripheral nervous system disorder first begins with the very careful history to understand how the symptoms started and how they affect the patient. From the history we extend to the physical exam,.
Blood turned into nerve cells by Canadian researchers 2015 HD
Blood turned into nerve cells by Canadian researchers Mick Bhatia, director of McMaster University's Stem Cell and Cancer Research Institute, says his lab hopes to eventually develop neurons that could one day be transplanted into patients to restore healthy brain cells as a treatment for various diseases, like Alzheimer's. JD HowellMcMaster UniversityCanadian Press Canadian scientists have discovered how to turn a simple blood sample from a man or woman into a variety of nerve cells, including those that are responsible for pain, numbness and other sensations The technology will allow researchers to test potential drugs for treating pain using the nerve cells in a lab, all based on an individual patient's own genetic signature, said Mick Bhatia, who led the team of researchers at McMaster University in Hamilton.
Ow we can take easy to obtain blood samples and make the main cell types of neurological systems the central nervous system and the peripheral nervous system in a dish that is specialized for each patient, said Bhatia, director of McMaster's Stem Cell and Cancer Research Institute. Up until now, there has been no good way to get access to human neural cells to test or study, Bhatia told CBC News. While researchers can buy certain kinds of rat neural cell lines, they don't consistently respond the way human neural cells do.
What Is The Future Of Robotic Limbs
You know what will be cool about the future besides jetpaks and equality Robotic arms. And surprisingly they're not too far away. Hey guys, Julia here for Dnews Artificial limbs have come a long way since the days of Pirate Joe's Peg Leg. Today's prosthetics are made of state of the art materials and cutting edge technology. They're made of titanium, carbon fiber, andor silicone. These materials are tough, lighter and can even be designed to look lifelike. They stay on by a few different mechanisms like suspension or suction. Suspension involves.
Some type of straps or sleeves. Suction works because the new limb might be custom made to perfectly fit to the remaining natural limb. Some devices can be controlled by the body, in a kind of pulley system, not surprisingly called body powered. Others can be controlled by switches or buttons. While fit and materials get progressively more advanced, so does the technology. Most new robotic limbs are myoelectriccontrolled, meaning muscles in the remaining limb naturally create electrical signals that are picked up by electrodes in the prosthetic. For the past few decades medical technology allowed patients to control their device through.
Electrodes placed on the skin. But that's an imperfect design, moving or sweating might dislodge the electrodes. So scientists are looking to the future. Recently a report published in the journal Science Translational Medicine talked about a robotic arm that uses what's called a Brnemark titanium implant which attaches the prosthetic directly to the skeleton in a process called osseointegration. And just like it sounds, this process fuses the bone to a titanium piece which sits outside of the limb, which the robotic arm attaches to. To control the device, the technology goes a step beyond the current myoelectric types.
It uses Targeted Muscle Reinnervation or TMR to hook up the prosthetic to nerves INSIDE the patient's body. The process takes nerves from the amputated limb and puts them on a spare muscle like the pectoral, the target muscle. Once these nerves start to regrow they can be activated by thought. Electrodes surrounding the muscle and nerves can then control the prosthetic. Sounds pretty futuristic right Yet something seems to be missing. The sensation of touch. Current techniques use sensory substitution to provide feedback, like a buzz or vibration when the limb comes into contact with something. In research presented in the journal Plastic.
And Reconstructive Surgery researchers look for a way to restore a patient's ability to feel. The researchers say this would reduce the cognitive burden of relying on vision alone to navigate the environment. A robotic hand with the ability to feel would have to be able to take a sensation like hot or cold or pressure like firm or soft and translate that into electrical signals. The different sensations could create a different signal like it could vary in strength, frequency or duration. The researchers suggested using TMR to restore some type of sensation for the patient. Another.
Idea is a sensory regenerative peripheral nerve interface sRPNI, which would directly hook up a nerve with some sort of biological interface on the prosthetic. Or maybe light could brighten up the future. Optogenics might enable different light waves to control nerve signalling. Anything to make the electrical signalling devices smaller and more precise. Robotic legs too are taking great leaps into the future. Research published in the journal Science Translational Medicine explained recent advances in powered joints. Yeah that's right. Basically each joint in a robotic leg can have a little motor in it. This way it.
Detects pressure and angle and can send that information to the central nervous system. But more than that, the more advanced models can have a neural interface that enhances integration with the brain. This way they can sense a person's intention like the desire to move from a flat surface to climbing stairs. Either way the future of artificial limbs is gonna be awesome. Speaking of insane augmentations, Toyota has been doing some tinkering of their own with the TRD line of Toyota Trucks. Enhanced to rule the offroad! Do you have an artificial limb or know anyone who does Tell us your story down in the comments.
Peripheral Nerve Stimulation Migraine Treatment on DFWs Ask The Dr. DFW Tutorial 2
Mike Burger Welcome back to Ask The Doctor. I am your host, Mike Burger. Here to talk about a new procedure to alleviate migraines is Dr. Kenneth Reed from Reed Migraine Centers. Remember we are also taking your calls and email questions. The number is 18555MIGRAINE, or you can log on to our website at reedmigraine. Dr. Reed, who would qualify for this type of neurostimulation procedure, everyone that has a migraine or. Dr. Reed Absolutely not. Who is a candidate for this procedure It is probably the first.
Question that people ask, Am I a candidate It is actually pretty straightforward. This tends to work on most types of severe headaches, migraine, tension headaches. It is not for everybody. The candidate for this patient, if somebody has frequent severe headaches, maybe two or more times a week, and the key is they have tried more conservative treatment. This is not a first step in treatment. It is a surgical procedure, tends to be towards the end. People with headaches or a candidate that's gone to a headache specialist and neurologist.
Have been working with it, maybe several neurologists, medications or adjunctive treatment such as Botox, very often those will work and if they are working, you certainly don't need this, but oftentimes they don't work or if they don't work and there is really nothing left to do, that patient becomes a candidate, so frequent, severe headaches that have tried more conservative treatment, they are still having them, they're a candidate. Mike Burger Are there different types of migraine headaches Dr. Reed There are a lot of different types of migraine headaches. Migraine headaches,.
Some people just classify as a severe headache, but neurologically, they are very specific diagnoses. Patients that have them tend to know, they are going to neurologists, they can tell us the type. This treatment has been studied in several different types, classic migraines, common migraines, tension headaches, chronic daily headaches, cluster headaches and in all of the studies, it shows it to be very and similarly effective. Mike Burger How effective would you say the Reed procedure is Dr. Reed How effective is it Not everybody responds, but if they respond, it tends to.
Be dramatically effective. People describe it as getting their life back. I have my wife back. The children can function again. They are going back to school. They are enjoying life. A percentage, they'll describe over 80 to 90 improvement in the headaches, sometimes nearly complete resolution of the headaches. Mike Burger I just want to quickly mention. I went to YouTube and I saw the tutorial of the young lady. I think she is a sophomore in college now, had a migraine for nine months and this procedure literally gave her life.
Back. Dr. Reed Exactly so. Kim, who could not function, she had to withdraw from college, she was living with her parents. Here in Dallas, her dad is a wellknown orthopedic surgeon. She could literally not leave the house. About just over four years ago, they contacted us. We did the first step, which is test procedure to confirm that it works, and then we implanted the full system. This is four years later, she is virtually headachefree. She takes no medications, lives a full active lifestyle and is doing just great. Mike Burger She likes you a lot.
When you initially presented to the office, you presented with numbness, tingling, and irritation in the lower extremities and feet. We've managed this condition with our peripheral neuropathy program. How have you done with the management and how are you doing today Oh I'm feeling fine, I'm feeling great. When I came in here I thought I'd have to live with pain the rest of my life and it's great, really great. Well we're very very proud to have you here as a patient and congratulations on your results. Thank you doctor, thank you.
Home Remedies for Numbness In Hands Legs II II
Hi friends this is satvinder on F3 health beauty tips. Today i am going to share few home remedies for numbness in hands feet Numbness in hands in feet means there is lack of touch sensation. other symptoms may include tingling or burning sensation, sharp pain or weakness of the effective area Its a very common problem There are many causes including constant pressure on the hands feet exposure to cold object or nerve injury, fatigue, drinking Deficiency of Vitamin D12 or magnessium So, i am going to tell you few simple home remedies on numbness in hands feet.
The first one of warm compress the first thing you need to do is apply to the warm compress to the effective area. It increases your blood supply and relaxes your muscles just dip a cloth in warm water squeeze the excess water apply this warm compressor on the effected area for around 57 minutes Repeat several times in a day until the numbness is gone you can also enjoy some hot water also enjoy some heat pads. The second one is message Message the area where numbness is there.
It improves the blood circulation. Stimulates the nerves muscles improves the over all functions. Take any oil olive oil, coconut oil or mustard oil apply oil on the affected area message in a circular motion. you can repeat it as in when require The third one is exercise As you all know exercise improves the blood circulation oxygen to all parts of the body it prevents tingling sensation to any effective part of the body including eands feet Regular exercise improves mobility prevents many health problems.
Avoid remaining in same position while watching TV or at work avoid caffeine aerated drinks Include lots of fruits vegetables in your diet. Avoid process foods Drink ample amount of the water through out the day keep yourself hydrated And loose weight to reduce numbness in your feet toes. So, these were very few simple home remedies for numbness in your hands feet I hope it will be helpful to you Do subscribe to our channel also send us your comments. Thank you so much for watching my tutorial.
Treating Neuropathy and Nerve Pain in the Feet
Let me start with I'm a diabetic. I developed neuropathy, which basically you lose all sensation in the feet, but it's over a period of time. It was very painful. I would have sensations in my feet like I was standing on fire, walking on glass. Last October it got so bad that I couldn't sleep at night. Then I met Dr. Bullard, because he's just a great physician. I wouldn't think twice, I'd recommend him to anybody. Very compassionate, very thorough, I can't say enough about Dr. Bullard. He's just a great physician and I don't know.
If there's anything he couldn't do he could probably move mountains if he wanted to! Glen, probably one of the biggest questions people are asking you is what'd we do, what's happened. Of course, you had a tremendous improvement in your pain and the tingling and the numbness. Easiest explanation is, to tell everybody, that this big nerve here, which is on the inside part of your left foot, was getting strangled. There was a noose around it. What we did is we went in and loosened the noose, and that allows that nerve to begin to function and work like it's supposed.
To. Now, the sensation is coming back, it's something that's going to take time but I can feel more. My quality of life has greatly improved since I had the procedure done by Dr. Bullard. There's no other physician that I would recommend. Glen, in the next couple weeks, what we're going to do is make sure that the swelling is improving, hopefully begin to transition you out of your compression socks, because I know it's kind of hot right now, and then look at making sure that your shoe gear and things like that are where they're supposed.
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